When Samuel Leeper was born on 5 May 1800, in United States, his father, Charles Leeper, was 53 and his mother, Margaret Miller, was 43. He married Nancy Perrine on 5 August 1822, in Maysville, Mason, Kentucky, United States. They were the parents of at least 5 sons and 5 daughters. He lived in Whitewater Township, Hamilton, Ohio, United States in 1830 and McLean, Illinois, United States in 1840. He died on 29 October 1845, in Heyworth, McLean, Illinois, United States, at the age of 45, and was buried in Heyworth Cemetery, Heyworth, McLean, Illinois, United States.