When Jesse Irish Sr. was born on 26 September 1712, in Tiverton, Newport, Rhode Island, United States, his father, Jonathan Irish, was 34 and his mother, Mary Taylor, was 29. He married Mary Albee on 21 March 1732. They were the parents of at least 8 sons and 5 daughters. He lived in Oswego, Oswego, New York, United States for about 6 years. He died in 1778, in Danby, Rutland, Vermont, United States, at the age of 66.