When Isaac David Alyea was born in 1790, in Vernon, Sussex, New Jersey, United States, his father, David Isaac Alyea, was 24 and his mother, Rebecca Ingersoll, was 21. He married Keziah Smith on 25 September 1817, in Brookville, Franklin, Indiana, United States. They were the parents of at least 4 sons and 1 daughter. He died in 1830, in LaPorte, LaPorte, Indiana, United States, at the age of 40.