When Nancy Susan Adkisson was born on 3 October 1865, in Alabama, United States, her father, Thomas Hamilton Adkisson, was 23 and her mother, Nancy Ardella Hodo, was 26. She married James Hartwell Smith on 2 November 1880, in Leon, Texas, United States. They were the parents of at least 5 sons and 9 daughters. She lived in Alexander, Erath, Texas, United States in 1920 and Dublin, Erath, Texas, United States in 1930. She died on 2 January 1950, in Fort Worth, Tarrant, Texas, United States, at the age of 84, and was buried in Dublin, Erath, Texas, United States.