When William Trego was born on 3 June 1693, in Honey Brook, Chester, Pennsylvania, United States, his father, Peter Trego Sr, was 43 and his mother, Judith Michaeux, was 38. He married Margaret Moore on 26 August 1717, in Goshen Township, Chester, Pennsylvania, British Colonial America. They were the parents of at least 4 sons and 6 daughters. He died in 1770, in Goshen MM, Chester, Pennsylvania, United States, at the age of 77.