When Isaac Newton Giffen was born in 1843, in Ohio, United States, his father, Matthew Griffith, was 34 and his mother, Lucinda Stewart, was 28. He married Arminda Viola Hackett on 27 June 1886, in Benton, Missouri, United States. They were the parents of at least 1 daughter. He lived in Mason, Illinois, United States in 1860 and Election Precinct 3 East Grand Plains, Chaves, New Mexico, United States in 1910. He died in 1891, in Missouri, United States, at the age of 48, and was buried in Edwards, Benton, Missouri, United States.