When Frank Thompkins was born on 8 August 1906, in Butler, Choctaw, Alabama, United States, his father, Milton Thompkins, was 25 and his mother, Mattie Jane Hill, was 24. He married Amerson Deatrice Watkins on 18 January 1933, in Butler, Choctaw, Alabama, United States. They were the parents of at least 2 sons. He lived in Election Precinct 2, Choctaw, Alabama, United States for about 10 years and Tuscumbia, Colbert, Alabama, United States in 1940. He died in May 1970, in Butler, Choctaw, Alabama, United States, at the age of 63.