When John S Squires was born on 26 September 1793, in Fort Edward, Fort Edward, Washington, New York, United States, his father, Samuel Squires, was 44 and his mother, Annie Bates, was 42. He married Elcy Hopkins on 19 September 1819, in Fort Edward, Fort Edward, Washington, New York, United States. They were the parents of at least 3 sons and 2 daughters. He died on 6 March 1835, in Washington, New York, United States, at the age of 41.