When Isaphine Luckie was born on 11 June 1849, in Macedonia, Lowndes, Alabama, United States, her father, William Foster Luckie, was 46 and her mother, Mahalia Erates Manning, was 37. She lived in Steep Creek, Lowndes, Alabama, United States in 1880 and Election Precinct 7 Hickory Hill, Lowndes, Alabama, United States in 1910. She died on 12 January 1922, in Forest Home, Butler, Alabama, United States, at the age of 72.