When Jess Humphrey was born on 29 September 1766, in Bucks, Pennsylvania, United States, his father, Cpt. Thomas Marcus Humphrey Jr., was 24 and his mother, Mary Humphrey, was -59. He married Winey Lee Morris on 20 January 1790, in Loudoun, Virginia, United States. They were the parents of at least 2 sons and 3 daughters. He died on 11 January 1815, in Loudoun, Virginia, United States, at the age of 48, and was buried in Bloomfield, Loudoun, Virginia, United States.