When Isaac Odell was born in 1803, in Cocke, Tennessee, United States, his father, Caleb O'Dell, was 22 and his mother, Rachel Clevenger, was 25. He married Mary Martin Gammill on 8 May 1828, in Tennessee, United States. They were the parents of at least 4 sons and 5 daughters. He lived in Pleasant Grove Township, Coles, Illinois, United States in 1860 and Illinois, United States in 1870. He died on 10 January 1872, in Lerna, Coles, Illinois, United States, at the age of 69, and was buried in Trilla, Coles, Illinois, United States.