When Mary Ellen Thompson was born on 22 August 1881, in Lee, Kentucky, United States, her father, Andrew Jackson Thompson, was 42 and her mother, Mary Katherine Lucas, was 34. She married Archelous Boone Chambers on 9 March 1899, in Lee, Kentucky, United States. They were the parents of at least 6 sons and 2 daughters. She lived in Campton, Wolfe, Kentucky, United States in 1930 and Magisterial District 3 New Virginia, Lee, Kentucky, United States for about 5 years. She died on 3 June 1974, in Lee, Kentucky, United States, at the age of 92, and was buried in Chambers Cemetery, Athol, Lee, Kentucky, United States.