When Hiram Lewis was born about 1779, in North Carolina, United States, his father, Edmund Lewis, was 27 and his mother, Mary Green, was 19. He married Agnes Carney on 3 March 1806, in Caswell, North Carolina, United States. They were the parents of at least 6 sons and 5 daughters. He lived in Caswell, North Carolina, United States in 1810 and Gallatin, Sumner, Tennessee, United States in 1820. He died before February 1833, in Sumner, Tennessee, United States, at the age of 54.