When Rubye Loper was born on 9 November 1901, in Chatom, Washington, Alabama, United States, her father, Edward Box Loper, was 48 and her mother, Dolly Isabelle Ferguson, was 45. She married Simeon Buford Simpson Jr on 3 August 1921, in Washington, Alabama, United States. They were the parents of at least 1 son and 1 daughter. She lived in Citronelle, Mobile, Alabama, United States in 1920 and Healing Springs, Washington, Alabama, United States in 1930. She died on 25 January 1976, in Millry, Washington, Alabama, United States, at the age of 74, and was buried in Millry, Washington, Alabama, United States.