When Isaac Andrews was born on 12 January 1775, in Norton, Bristol, Massachusetts Bay Colony, British Colonial America, his father, Joseph Andrews, was 56 and his mother, Sarah Torrey, was 45. He married Hannah Briggs on 16 June 1802, in Norton, Bristol, Massachusetts, United States. They were the parents of at least 5 sons and 2 daughters. He died on 27 October 1862, in Sherburne, Sherburne, Chenango, New York, United States, at the age of 87, and was buried in Sherburne, Sherburne, Chenango, New York, United States.