When Nicholas Iwardby was born about 1422, in Quainton, Buckinghamshire, England, his father, Lord John Iwardby, was 32 and his mother, Lady Katherine Missenden, was 14. He married Elizabeth Hampden about 1446, in Ewerby, Lincolnshire, England, United Kingdom. They were the parents of at least 3 sons. He died in 1462, in London, England, at the age of 40, and was buried in St Bride's Church Fleet Street, London, England, United Kingdom.