When Otis Parkhurst was born on 20 September 1781, in Milford, Worcester, Massachusetts, United States, his father, Nathaniel Parkhurst, was 35 and his mother, Sarah Brown, was 28. He married Sarah "Sally" Jones on 26 March 1803. They were the parents of at least 4 sons and 10 daughters. He died on 5 March 1869, in Milford, Worcester, Massachusetts, United States, at the age of 87, and was buried in Milford, Worcester, Massachusetts, United States.