When Lloyd Knowles was born on 24 December 1927, in Duplin, North Carolina, United States, his father, Alfred Frank Knowles, was 30 and his mother, Nannie Catherine Ball, was 35. He married Dorothy Jean Copeland on 3 December 1951, in Obion, Tennessee, United States. He lived in Richlands, Onslow, North Carolina, United States in 1930 and Albertson Township, Duplin, North Carolina, United States in 1940. He died on 6 March 1971, in Gila, Arizona, United States, at the age of 43, and was buried in Globe, Gila, Arizona, United States.