When Lewis Reynolds was born about 1825, in Clay, Kentucky, United States, his father, Pleasant W Reynolds, was 34 and his mother, Rebecca Henderson, was 31. He married Susan Jane Roberts on 29 August 1848, in Estill, Kentucky, United States. They were the parents of at least 4 sons and 2 daughters. He lived in Grand River Township, DeKalb, Missouri, United States in 1860 and Colfax Township, DeKalb, Missouri, United States for about 10 years. He died in 1880, in Missouri, United States, at the age of 55.