When John William Squires was born on 12 March 1781, in Bedford, Virginia, United States, his father, Uriah Erastus II Squires, was 33 and his mother, Elizabeth Trigg, was 24. He married Lockey Jones on 28 March 1808, in Bedford, Virginia, United States. They were the parents of at least 2 sons and 4 daughters. He lived in Santa Clara Judicial Township, Santa Clara, California, United States in 1860 and California, United States in 1870. He died on 16 February 1873, in Santa Clara, Santa Clara, California, United States, at the age of 91, and was buried in Mission City Memorial Park, Santa Clara, Santa Clara, California, United States.