When Mildred Barkley was born on 14 February 1922, in Greenville, South Carolina, United States, her father, Wade Hampton Barkley, was 41 and her mother, Eula G Sheffield, was 22. She lived in Greenville Township, Greenville, South Carolina, United States in 1940. She died on 11 November 1979, in Charleston, Charleston, South Carolina, United States, at the age of 57, and was buried in Greenville, South Carolina, United States.