When Isaac Andrews was born in 1715, in Little Egg Harbor Township, Burlington, New Jersey, United States, his father, Edward Andrews, was 38 and his mother, Sarah Ong, was 38. He married Elizabeth Elfreth on 21 September 1738. They were the parents of at least 4 sons and 6 daughters. He died in 1750, in United States, at the age of 35, and was buried in Woodbury, Gloucester, New Jersey, United States.