When Honor Wells was born on 10 December 1724, in Baltimore, Maryland, British Colonial America, her father, James Wells, was 48 and her mother, Ann Thornborough, was 34. She married William M. Holmes Jr on 15 August 1738, in Baltimore, Maryland, British Colonial America. They were the parents of at least 4 sons and 5 daughters. She died on 28 March 1816, in Holidays Cove, Hancock, Virginia, United States, at the age of 91, and was buried in Saint Johns Cemetery, Marion, West Virginia, United States.