When Edward Alexander Talbott Sr. was born on 5 March 1818, in Anne Arundel, Maryland, United States, his father, Richard Talbott Sr., was 34 and his mother, Sarah Ann Fairall, was 23. He married Mary Jane Wareum on 19 June 1841, in Baltimore, Baltimore, Maryland, United States. They were the parents of at least 2 sons and 3 daughters. He lived in Maryland, United States in 1870. He died on 1 November 1890, in Ellicott City, Howard, Maryland, United States, at the age of 72, and was buried in Ellicott City, Howard, Maryland, United States.