When Wiley Huffman Andrews was born on 4 November 1888, in Abingdon, Washington, Virginia, United States, his father, Jasper Joseph Anders Jr, was 27 and his mother, Thursia J Bedwell, was 25. He married Ella Mae Taylor on 1 January 1918, in Grayson, Virginia, United States. They were the parents of at least 3 sons and 1 daughter. He lived in Gap Civil Township, Alleghany, North Carolina, United States in 1900 and Elk Creek, Grayson, Virginia, United States in 1920. He died on 29 October 1965, in Winston-Salem, Forsyth, North Carolina, United States, at the age of 76, and was buried in Woodland Cemetery, Winston-Salem, Forsyth, North Carolina, United States.