When Margaret Thompson Spaulding was born on 24 September 1852, in New York City, New York, United States, her father, Henry Foster Spalding, was 35 and her mother, Rose Thompson, was 27. She married Dr. James Montford Schley Jr. on 14 October 1874, in Manhattan, New York City, New York, United States. They were the parents of at least 2 sons and 3 daughters. She died on 1 March 1911, in Manhattan, New York City, New York, United States, at the age of 58.