When George B. Greenup was born on 15 June 1812, in Virginia, United States, his father, Thomas Witten Greenup, was 42 and his mother, Catherine McIntosh, was 37. He married Rebecca Dailey on 22 May 1839, in McDonough, Illinois, United States. They were the parents of at least 2 daughters. He died on 5 September 1844, in McDonough, Illinois, United States, at the age of 32, and was buried in Dailey, Champaign, Illinois, United States.
English (Lancashire and Cumberland): habitational name from Greenup Edge in Borrowdale (Cumberland), early recorded as Grenehope.