When William J. Trego Sr. was born on 16 March 1744, in Upper Makefield Township, Bucks, Pennsylvania, British Colonial America, his father, John Trego Cartledge, was 28 and his mother, Hannah Lester Dickerson, was 24. He married Rebecca Hibbs on 14 September 1768, in Wrightstown MM, Bucks, Pennsylvania, British Colonial America. They were the parents of at least 7 sons and 4 daughters. He died on 23 December 1826, in Upper Makefield Township, Bucks, Pennsylvania, United States, at the age of 82, and was buried in Wrightstown Friends Meeting Cemetery, Wrightstown, Wrightstown Township, Bucks, Pennsylvania, United States.