When Margarida Affonso de Lyra was born in 1500, in Ilha da Graciosa, Azores, Portugal, her father, Pedro Anes Carração, was 40 and her mother, Margarida Vaz Freire, was 40. She married Bartolomeu Dias Picanço in 1500, in Mértola, Beja, Portugal. They were the parents of at least 1 son and 3 daughters. She died in her hometown.