When Henry Francis Spease was born on 3 October 1887, his father, William Edward Spease, was 39 and his mother, Catharine Louisa Rose, was 32. He married Mabel Evelyn Zeigler on 15 March 1911, in Dellville, Wheatfield Township, Perry, Pennsylvania, United States. They were the parents of at least 1 son and 2 daughters. He lived in Wheatfield Township, Perry, Pennsylvania, United States for about 10 years and East Choteau Township, Douglas, South Dakota, United States for about 15 years. He died on 25 January 1969, at the age of 81, and was buried in Mitchell, Davison, South Dakota, United States.