When Margaret Griffing was born on 16 April 1788, in Rhinebeck, Dutchess, New York, United States, her father, Stephan Griffing, was 34 and her mother, Elizabeth Streit Uhl, was 24. She married Duncan Cameron in 1807. They were the parents of at least 4 sons and 7 daughters. She lived in Athol, Thurman, Warren, New York, United States in 1850 and Warren, New York, United States in 1860. She died on 23 January 1864, in Thurman, Thurman, Warren, New York, United States, at the age of 75, and was buried in Thurman, Thurman, Warren, New York, United States.