When Amos John Colombus Whitmire was born on 20 January 1849, in Rabun, Georgia, United States, his father, William Rolin "Billie" Whitmire, was 26 and his mother, Hannah Rosseta McCurry, was 21. He married Melissa Jayne Williams on 1 August 1867, in Macon, Georgia, United States. They were the parents of at least 7 sons and 3 daughters. He lived in District 556, Rabun, Georgia, United States in 1900 and Clayton, Rabun, Georgia, United States in 1920. He died on 6 August 1926, in Walhalla, Oconee, South Carolina, United States, at the age of 77, and was buried in Georgia, United States.