When William Reynolds was born on 7 May 1791, in Patrick, Virginia, United States, his father, Joseph Reynolds, was 31 and his mother, Sarah or Sally Perkins, was 27. He married Nancy Burnett on 16 March 1820, in Patrick, Virginia, United States. They were the parents of at least 7 sons and 10 daughters. He lived in Union Township, Champaign, Ohio, United States in 1860. He died on 3 November 1856, in Jefferson Township, Johnson, Missouri, United States, at the age of 65, and was buried in Warrensburg, Johnson, Missouri, United States.