When Margaret Isabel Talbot was born on 2 November 1878, her father, John Gilbert Talbot, was 43 and her mother, Muriel Sarah Lyttelton, was 40. She married Randal Mark McDonnnell on 2 July 1904, in Mark Beech, Kent, England. They were the parents of at least 1 son and 1 daughter. She lived in London, Middlesex, England in 1881 and Kensington, London, England, United Kingdom in 1911. She died on 10 April 1974, at the age of 95.