When Nancy M. Williams was born on 7 February 1812, in Salisbury, Salisbury, Herkimer, New York, United States, her father, William Williams, was 38 and her mother, Mahetabel Stearns, was 36. She married Lemuel Page Wetherby on 30 January 1832, in Summer Hill, Summerhill, Cayuga, New York, United States. They were the parents of at least 3 sons and 3 daughters. She died on 15 November 1844, in Red Creek, Wolcott, Wayne, New York, United States, at the age of 32, and was buried in Red Creek, Wolcott, Wayne, New York, United States.