When Dorothy Howe was born on 4 May 1730, in Marlborough, Middlesex, Massachusetts, United States, her father, Joseph Howe, was 33 and her mother, Ruth Brigham, was 26. She married Capt Cyprian Howe on 20 November 1750, in Marlborough, Middlesex, Massachusetts, United States. They were the parents of at least 1 son and 3 daughters. She died on 30 May 1764, in United States, at the age of 34.