When William E. Wyatt was born on 1 January 1858, in New York City, New York, United States, his father, Christopher Billop Wyatt, was 32 and his mother, Mary Angelica Croghan, was 39. He married Jane Kirby on 7 June 1881, in Manhattan, New York City, New York, United States. They were the parents of at least 2 sons and 2 daughters. He lived in New York City, New York County, New York, United States in 1880 and Manhattan, New York City, New York, United States for about 10 years. He died on 17 April 1932, in Toronto, York, Ontario, Canada, at the age of 74.