When Samuel Tuttle was born on 10 February 1715, in Chelsea, Suffolk, Massachusetts Bay Colony, British Colonial America, his father, Edward Tuttle, was 36 and his mother, Joanna Floyd, was 28. He married Anna Sargent on 11 May 1736. They were the parents of at least 6 sons and 4 daughters. He lived in Boston, Suffolk, Massachusetts, United States in 1714. He died on 12 February 1776, at the age of 61.