When Samuel B. Bowles was born on 15 April 1773, in Hagerstown, Washington, Maryland, United States, his father, Thomas Bowles Jr., was 29 and his mother, Eleanor Price, was 33. He married Mary Miller in 1795, in United States. They were the parents of at least 1 son and 2 daughters. He died about 1806, at the age of 33.