When John Misener was born on 27 January 1834, in Fowler Township, Trumbull, Ohio, United States, his father, Richard Hall Mizner, was 29 and his mother, Eliza Thompson, was 27. He married Sylvia Adeline Tyrrell on 31 March 1857, in Fowler, Trumbull, Ohio, United States. They were the parents of at least 1 daughter. He lived in Vernon Township, Trumbull, Ohio, United States in 1850. He died on 2 January 1862, in Trumbull, Ohio, United States, at the age of 27, and was buried in Fowler, Trumbull, Ohio, United States.