When Louisa Fielder was born on 12 October 1827, in Clarksville, Pike, Missouri, United States, her father, John Fielder, was 36 and her mother, Eliza Sarah West, was 34. She married James Henry Settles on 19 October 1843, in Pike, Missouri, United States. They were the parents of at least 8 sons and 4 daughters. She lived in Missouri, United States in 1870 and Bethlehem Township, Henry, Missouri, United States in 1880. She died on 30 September 1895, in Henry, Missouri, United States, at the age of 67, and was buried in Oak Grove Cemetery, Clinton Township, Henry, Missouri, United States.