When Phebe Tirrell was born on 2 October 1725, in Abington, Plymouth, Massachusetts Bay Colony, British Colonial America, her father, Samuel Tirrell Sr., was 38 and her mother, Mary Nash, was 25. She married Moses Reed on 10 May 1750, in Abington, Plymouth, Massachusetts Bay Colony, British Colonial America. They were the parents of at least 2 sons and 1 daughter. She died on 18 August 1759, in her hometown, at the age of 33, and was buried in Mount Zion Cemetery, Whitman, Plymouth, Massachusetts Bay Colony, British Colonial America.