When Dr Isaac Hough was born on 15 November 1726, in Bucks, Pennsylvania, United States, his father, John Hough, was 33 and his mother, Elizabeth Lyddon Taylor, was 20. He married Edith Hart on 24 September 1748, in Warminster Township, Bucks, Pennsylvania, United States. They were the parents of at least 7 sons and 4 daughters. He died on 13 April 1786, in Warminster Township, Bucks, Pennsylvania, United States, at the age of 59, and was buried in Old School Baptist Meeting House Cemetery, Southampton, Bucks, Pennsylvania, United States.