When John Bowie Pendleton was born on 22 August 1805, in Culpeper, Virginia, United States, his father, William Pendleton, was 57 and his mother, Elizabeth Daniel, was 46. He married Elizabeth Ann Odell on 1 November 1831, in Culpeper, Virginia, United States. They were the parents of at least 6 sons and 3 daughters. He lived in Marion, Missouri, United States in 1870 and Marion Township, Monroe, Missouri, United States in 1880. He died on 24 December 1885, in Monroe, Missouri, United States, at the age of 80.