When Clarke Reynolds Lillibridge was born on 4 August 1779, in Exeter, Washington, Rhode Island, United States, his father, Jonathan Lillibridge, was 27 and his mother, Mary Reynolds, was 25. He married Lydia Lewis on 14 February 1799, in Coventry, Kent, Rhode Island, United States. They were the parents of at least 9 sons and 3 daughters. He lived in Connecticut, United States in 1779. He died on 21 July 1864, in Griswold, New London, Connecticut, United States, at the age of 84, and was buried in Pachaug Cemetery, Griswold, New London, Connecticut, United States.