When Thomas Wilcox was born on 12 May 1689, in Exeter, Devon, England, United Kingdom, his father, Israel Wilcox I, was 32 and his mother, Sarah Savage, was 31. He married Elizabeth Cole on 3 June 1727, in Wilmington, New Castle, Delaware, United States. They were the parents of at least 8 sons and 5 daughters. He died on 11 November 1779, in Delaware Township, Northumberland, Pennsylvania, British Colonial America, at the age of 90, and was buried in Glen Mills, Thornbury Township, Delaware, Pennsylvania, United States.