When Serena East was born on 6 May 1824, in Lawrence, Mississippi, United States, her father, Isaac East, was 27 and her mother, Margaret 'Peggy' Smith, was 24. She married Caleb D Bailey on 24 June 1844, in Copiah, Mississippi, United States. They were the parents of at least 6 sons and 6 daughters. She lived in Meadville, Franklin, Mississippi, United States in 1870 and Wesson, Copiah, Mississippi, United States in 1880. She died on 6 November 1886, in Copiah, Mississippi, United States, at the age of 62, and was buried in Wesson Cemetery, Wesson, Copiah, Mississippi, United States.