When Nancy Ann Appleby was born on 11 January 1784, in Coeymans, Coeymans, Albany, New York, United States, her father, Abraham Appleby, was 26 and her mother, Sarah Travis, was 30. She married John Brewster Lester about 1799, in Coeymans, Coeymans, Albany, New York, United States. They were the parents of at least 5 sons and 4 daughters. She lived in Sempronius, Cayuga, New York, United States in 1850. She died on 9 August 1853, in Tarrytown, Greenburgh, Westchester, New York, United States, at the age of 69.