When Florence Lee Thompson was born on 29 July 1862, her father, John Frederick Thompson, was 25 and her mother, Sarah Ann Miller, was 23. She married Abraham Lindsay Smith on 28 December 1886, in Davidson, North Carolina, United States. They were the parents of at least 1 son and 2 daughters. She died on 4 April 1943, in Lexington, Davidson, North Carolina, United States, at the age of 80, and was buried in Lexington City Cemetery, Lexington, Davidson, North Carolina, United States.