When Isaac Oberholtzer was born on 24 May 1838, in Waterloo, Waterloo, Ontario, Canada, his father, Jacob Moyer Oberholtzer, was 38 and his mother, Hannah Erb, was 25. He married Mary Ann Wismer on 30 September 1863, in Waterloo, Waterloo, Ontario, Canada. They were the parents of at least 3 sons and 3 daughters. He lived in Howick Township, Huron, Ontario, Canada in 1871 and Kitchener, Waterloo, Ontario, Canada in 1911. He died on 24 February 1887, in Berlin, Waterloo, Ontario, Canada, at the age of 48, and was buried in Berlin, Waterloo, Ontario, Canada.
Swiss German and German: from Middle High German ober ‘above’ + holz ‘wood’ + the suffix -er, denoting an inhabitant, a topographic name for someone who lived above a wood or on the far side of it, or alternatively a habitational name for someone who lived in a place known as Oberholtz (‘upper wood’). This surname is almost extinct in Germany; in Switzerland it is common in the spelling Oberholzer . Compare Overholser , Overholt and Overholtzer .